Menopausal hormone therapy: transdermal route of administration
نویسندگان
چکیده
منابع مشابه
Haemostatic activation in post-menopausal women taking low-dose hormone therapy: less effect with transdermal administration?
Hormone therapy (HT) increases the risk of cardiovascular and thromboembolic disease in post-menopausal women. Recent studies have suggested that prothrombotic mechanisms are likely to be involved. Transdermal HT avoids the first-pass effect of oestrogen in the liver and may have a less marked effect on the haemostatic system than equivalent oral preparations. The majority of studies have compa...
متن کاملThe effect of hormone replacement therapy and route of administration on selected cardiovascular risk factors in post-menopausal women.
BACKGROUND There is increasing use of hormone replacement therapy (HRT) by post-menopausal women. Observational epidemiological studies have shown reductions in cardiovascular risk factors in HRT users in the USA, but no randomized controlled trials of HRT have been carried out in the primary practice setting. Previous studies of cardiovascular risk factors have shown a variety of responses acc...
متن کاملDoes the route of administration for estrogen hormone therapy impact the risk of venous thromboembolism? Estradiol transdermal system versus oral estrogen-only hormone therapy.
OBJECTIVE The aim of this study was to quantify the magnitude of risk reduction for venous thromboembolism events associated with an estradiol transdermal system relative to oral estrogen-only hormone therapy agents. METHODS A claims analysis was conducted using the Thomson Reuters MarketScan database from January 2002 to October 2009. Participants 35 years or older who were newly using an es...
متن کاملDifferential effects of oral and transdermal menopausal hormone therapy on prostacyclin and thromboxane in platelets
Abstract Menopausal hormone therapies (MHT) may increase thrombotic risk but modulate endothelial function and reduce development of vascular lesions. This study compared effects of MHT on prostanoid-modulated adenosine triphosphate (ATP) secretion from platelets in relationship with endothelial reactive hyperemia (RH) index and carotid intima medial thickness (CIMT). Participants were healthy,...
متن کاملEffect of transdermal hormone therapy on platelet haemostasis in menopausal women.
INTRODUCTION Despite the undeniably positive effect on the quality of life of menopausal women, menopausal hormone therapy (HT) also has negative side-effects, which include, among others, thromboembolic complications. OBJECTIVE To assess the effect of a popular type of this therapy - transdermal HT on platelet hemostasis, which plays a significant role in intravascular coagulation. MATERIA...
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ژورنال
عنوان ژورنال: Menopausal Review
سال: 2012
ISSN: 1643-8876
DOI: 10.5114/pm.2012.30230