Medical Management of Hereditary Optic Neuropathies

Medical Management of Hereditary Optic Neuropathies

Hereditary optic neuropathies are diseases affecting the optic nerve. The most common are mitochondrial hereditary optic neuropathies, i.e., the maternally inherited Leber's hereditary optic neuropathy (LHON) and dominant optic atrophy (DOA). They both share a mitochondrial pathogenesis that leads to the selective loss of retinal ganglion cells and axons, in particular of the papillo-macular bu...

Medical Rehabilitation in Hereditary Neuropathies

Oxydative Metabolism in Optic Nerve Myelin: New Perspectives in Hereditary Optic Neuropathies

ANT Adenosine Nucleotide Translocase; BSA Bovine Serum Albumin; CLSM Confocal Laser Scanning Microscopy; CNS Central Nervous System; EGTA Ethylene Glycol Tetraacetic Acid; ETC Electron Transport Chain; GA Glutaraldehyde; Ide, Idebenone; IM Isolated Myelin; MBP Myelin Basic Protein; LHON LeberHereditary Optic Neuropathy; MW MolecularWeight; NS Nervous System; OXPHOS Oxidative Phosphorylation; PB...

Mitochondrial optic neuropathies.

AutoiMMune/inflAMMAtory optic neuropAthies

InTRoDUCTIon Inflammatory, demyelinating optic neuritis is one of the most common optic neuropathies in young adults. It occurs idiopathically, or in association with multiple sclerosis, and follows a typical course of progressing visual dysfunction often with pain for one – two weeks, followed by significant resolution over the next few weeks. Due to the characteristic presentation and frequen...