Mechanisms of Varicella-Zoster Virus Neuropathogenesis in Human Dorsal Root Ganglia
نویسندگان
چکیده
منابع مشابه
Mechanisms of varicella-zoster virus neuropathogenesis in human dorsal root ganglia.
Varicella-zoster virus (VZV) is a human alphaherpesvirus that infects sensory ganglia and reactivates from latency to cause herpes zoster. VZV replication was examined in human dorsal root ganglion (DRG) xenografts in mice with severe combined immunodeficiency using multiscale correlative immunofluorescence and electron microscopy. These experiments showed the presence of VZV genomic DNA, viral...
متن کاملRevision 1 : JVI 02592 - 07 1 Mechanisms of Varicella - Zoster Virus Neuropathogenesis in Human Dorsal Root Ganglia
2 Varicella-zoster virus (VZV) is a human alphaherpesvirus that infects sensory ganglia 3 and reactivates from latency to cause herpes zoster. VZV replication was examined in human 4 dorsal root ganglia (DRG) xenografts in mice with severe combined immunodeficiency using 5 multiscale correlative immunofluorescence and electron microscopy (IF-EM). These 6 experiments showed the presence of VZV g...
متن کاملVaricella-zoster virus infection of human dorsal root ganglia in vivo.
Varicella-zoster virus (VZV) causes varicella and establishes latency in sensory ganglia. VZV reactivation results in herpes zoster. We developed a model using human dorsal root ganglion (DRG) xenografts in severe combined immunodeficient (SCID) mice to investigate VZV infection of differentiated neurons and satellite cells in vivo. DRG engrafted under the kidney capsule and contained neurons a...
متن کاملReactivated and latent varicella-zoster virus in human dorsal root ganglia.
Ganglia obtained at autopsy were examined by in situ hybridization from one patient with zoster (also called herpes zoster or shingles), two varicella-zoster virus (VZV)-seropositive patients with clinical evidence of zoster, one VZV-seronegative child, and one fetus. Ganglia positive for VZV had a hybridization signal in both neuronal and nonneuronal satellite cells. Ganglia obtained from the ...
متن کاملSimian varicella virus DNA in dorsal root ganglia.
Clinical, pathological, immunological, and virological evidence suggests that simian varicella virus (SVV) infection of primates is the counterpart of varicella-zoster virus infection of humans. To determine whether these two viruses share similarities in their properties during latency, we analyzed ganglia and brain of an African green monkey experimentally infected with SVV for the presence o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Virology
سال: 2008
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.02592-07