Matrix metalloproteinase-7, -8, -9, -15, and -25 in minor salivary gland adenoid cystic carcinoma

Knowledge on the role of matrix metalloproteinases (MMPs) in adenoid cystic carcinoma (ACC) is limited. MMPs are capable degrading almost all extracellular and pericellular components to promote invasion metastasis. This study aimed evaluate immunohistochemical expression MMP-7, -8, -9, -15, -25 ACC relate results with clinicopathological factors survival. The included 68 patients minor salivary gland treated at Helsinki University Hospital (Helsinki, Finland) 1974–2012. Samples from 52 were available, consisting 44 primary tumours eight recurrent tumours. We scored immunostaining analysed immunoscore against clinical pathological parameters using statistical correlation test. MMP-9 immunoexpression pseudocysts peritumoural inflammatory cells associated better survival fewer treatment failures. High tumoural MMP-7 MMP-15 poorer high advanced stage regional recurrences. Tumour did not show MMP-8 immunopositivity. These suggest that may contribute carcinogenesis different roles. -9 can stimulate signalling pathways tissue modulation metastatic potential. reflect prognosis.