Maternal serum adipokines and inflammatory markers at late gestation and newborn weight in mothers with and without gestational diabetes mellitus

Objectives: Maternal obesity increases the risk of gestational diabetes mellitus (GDM) and is positively correlated with neonatal increasing adiposity in both young adult offspring. secreted factors from adipose tissue such as adipokines inflammatory cytokines may regulate fetal growth. This study investigated associations between maternal markers at late gestation, anthropometric characteristics mothers without GDM. Material methods: The included 65 women GDM pregnant normal glucose tolerance evaluated time term elective Caesarean section. Adiponectin, leptin, resistin, adipsin, neutrophil gelatinase-associated lipocalin (NGAL), nerve growth factor (NGF), monocyte chemotactic protein-1 (MCP-1) tumor necrosis factor-alpha (TNF-alpha) concentrations were measured serum by multiplex immunoassay using Magpix technology. C-reactive protein (CRP) was a particle-enhanced turbidimetric variables assessed. association birthweight individual biomarkers analyzed multivariate logistic regression adjusted for factors. Results: NGAL NGF not significantly associated higher birthweight. observed CRP, MCP-1 TNF-alpha levels. Regression analysis showed that an independent (p = 0.046). Conclusions: These results suggest involvement gestation GDM, could play major role.