Mast cells as initiators of immunity and host defense
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چکیده
منابع مشابه
Mast cells as modulators of host defense in the lung.
Mast cells display a distinct spatial distribution in the lung where they are found preferentially in intraepithelial locations or in deeper tissue around blood vessels, bronchioles and mucus secreting glands. Yet the physiological role of these granule-laden cells is unknown. There are now intriguing signs that their distinctive distribution together with their intrinsic capacity to release la...
متن کاملBacterial Immunity and Host Defense
001 Abstract Microbes are the key players for deteriorating the host defense. They enter inside the host system, colonize the host cells, evade the host immunity and ultimately leads to tissue injury and ultimately disease. But the body cells are having strong immune system to combat with these aliens. There are two basic types of immune responses in body for bacterial degradation. Immune respo...
متن کاملMast cells impair host defense during murine Streptococcus pneumoniae pneumonia.
BACKGROUND Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia. Mast cells (MCs) are located mainly at the host-environment interface where they function as sentinels. OBJECTIVE Our goal was to study the role of MCs during pneumonia caused by S. pneumoniae. METHODS Lung tissue of patients who had died from pneumococcal pneumonia or a nonpulmonary c...
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Mast cells are known to be the effector cells of immediate-type allergy, but experimental evidence obtained during the last decade has revealed their role in innate and acquired immunity. Upon activation mast cells can undergo an anaphylactic or piecemeal degranulation or degranulation-independent mediator secretion, resulting in rapid or slow release of soluble mediators, such as serine protei...
متن کاملMast Cells as Cellular Sensors in Inflammation and Immunity
Mast cells are localized in tissues. Intense research on these cells over the years has demonstrated their role as effector cells in the maintenance of tissue integrity following injury produced by infectious agents, toxins, metabolic states, etc. After stimulation they release a sophisticated array of inflammatory mediators, cytokines, and growth factors to orchestrate an inflammatory response...
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ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 2001
ISSN: 0906-6705
DOI: 10.1034/j.1600-0625.2001.100101.x