Management and Outcomes in Children with Third-Generation Cephalosporin-Resistant Urinary Tract Infections
نویسندگان
چکیده
Abstract Background Third-generation cephalosporin-resistant urinary tract infections (UTIs) often have limited oral antibiotic options with some children receiving prolonged parenteral courses. Our objectives were to determine predictors of long therapy and the association between duration UTI relapse in third-generation UTIs. Methods We conducted a multisite retrospective cohort study <18 years presenting acute care at 5 children’s hospitals large managed organization from 2012 2017 Escherichia coli or Klebsiella spp. Long was ?3 days short/no 0–2 concordant antibiotics. Discordant antibiotics which pathogen non-susceptible. Relapse same organism within 30 days. Results Of 482 included, 81% female median age 3.3 (interquartile range: 0.8-8). Fifty-four (11.2%) received (median duration: 7 days). Predictors included <2 months (adjusted odds ratio [aOR] 67.3; 95% confidence interval [CI]: 16.4-275.7), (aOR 5.9; CI: 2.8-12.3), genitourinary abnormalities 5.4; 1.8-15.9). occurred 1 54 (1.9%) treated 6 428 (1.5%) (P = .57). 105 exclusively discordant antibiotics, 3 (2.9%, 0.6%-8.1%) experienced relapse. Conclusions associated months, options, abnormalities. rare not therapy. For UTIs further research is needed on effectiveness continued
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ژورنال
عنوان ژورنال: Journal of the Pediatric Infectious Diseases Society
سال: 2021
ISSN: ['2048-7193', '2048-7207']
DOI: https://doi.org/10.1093/jpids/piab003