M-type potassium channels modulate Schaffer collateral-CA1 glutamatergic synaptic transmission
نویسندگان
چکیده
منابع مشابه
Potentiation of Schaffer-Collateral CA1 Synaptic Transmission by eEF2K and p38 MAPK Mediated Mechanisms
The elongation factor 2 kinase (eEF2K), likewise known as CaMKIII, has been demonstrated to be involved in antidepressant responses of NMDA receptor antagonists. Even so, it remains open whether direct inhibition of eEF2K without altering up-stream or other signaling pathways affects hippocampal synaptic transmission and neuronal network synchrony. Inhibition of eEF2K by the selective and poten...
متن کاملChemical kindling enhances the Schaffer collateral-CAl pyramidal cell synaptic transmission in anesthetized rats
Epilepsy is one of the common disorders in human community. Clinical observations have shown that epileptic patients have often difficulty in learning and memory. Kindling is a laboratory model for studying epilepsy and its complications. This experiment was designed to study the effect of chemical kindling on Schaffer collateral-CA1 pyramidal cell synaptic transmission using pentylenetetrazole...
متن کاملchemical kindling enhances the schaffer collateral-cal pyramidal cell synaptic transmission in anesthetized rats
epilepsy is one of the common disorders in human community. clinical observations have shown that epileptic patients have often difficulty in learning and memory. kindling is a laboratory model for studying epilepsy and its complications. this experiment was designed to study the effect of chemical kindling on schaffer collateral-ca1 pyramidal cell synaptic transmission using pentylenetetrazole...
متن کاملGroup I mGluR Induced LTD of NMDAR-synaptic Transmission at the Schaffer Collateral but not Temperoammonic Input to CA1
NMDA receptors are composed of multiple subunits and are crucial in the induction of synaptic plasticity and learning and memory. In this study, application of the group I mGlu receptor agonist, DHPG, caused LTD of NMDA-EPSCs (DHPG-LTDNMDA) of the Schaffer collateral, but not of NMDA-EPSCs of the temperoammonic pathway onto CA1 neurons of the hippocampus. DHPGLTDNMDA did not alter the sensitivi...
متن کاملHCN1 channels constrain DHPG-induced LTD at hippocampal Schaffer collateral-CA1 synapses.
HCN channels play a fundamental role in determining resting membrane potential and regulating synaptic function. Here, we investigated the involvement of HCN channels in basal synaptic transmission and long-term depression (LTD) at the Schaffer collateral-CA1 synapse. Bath application of the HCN channel blocker ZD7288 (10 microM) caused a significant increase in synaptic transmission that was d...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2012
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2012.235820