منابع مشابه
Charge-assisted bond N+H mediates the gelation of amorphous lurasidone hydrochloride during dissolution.
Lurasidone hydrochloride (LH), the hydrochloride form of lurasidone with a charge-assisted bond N+H, is an atypical antipsychotropic agent for the treatment of schizophrenia. As a BCS class II drug, LH has a low oral bioavailability mainly due to its poor water solubility and low dissolution. In order to improve its solubility, amorphization of LH was performed and characterized. Unexpectedly, ...
متن کاملSAR Study, Synthesis, and Biological Activity of Lurasidone Hydrochloride : A New Drug for Treating Schizophrenia
includes attention and memory deficits and performance deficits. It is also known that these major symptoms often co-occur with mood disorders. Schizophrenia treatments involve medications, psychotherapeutic counseling, and social rehabilitation therapy. Medication is the first-choice treatment for the disease. However, some patients do not respond sufficiently to using existing drugs because o...
متن کاملLurasidone hydrochloride
In the crystal structure of the title compound, C(28)H(37)N(4)O(2)S(+)·Cl(-) [systematic name: 4-(1,2-benzothia-zol-3-yl)-1-({2-[(3,5-dioxo-4-aza-tricyclo-[5.2.1.0(2,6)]decan-4-yl)meth-yl]cyclo-hex-yl}meth-yl)piperazin-1-ium chloride], the anions and cations are linked by N-H⋯Cl hydrogen bonds. The crystal structure is further stabilized by C-H⋯π and C-H⋯O inter-actions.
متن کاملLATUDA® (lurasidone HCl) Tablets
---------------WARNINGS AND PRECAUTIONS----------- Cerebrovascular Adverse Reactions: An increased incidence of cerebrovascular adverse events (e.g., stroke, transient ischemic attack) has been seen in elderly patients with dementia-related psychoses treated with atypical antipsychotic drugs. (5.2). Neuroleptic Malignant Syndrome: Manage with immediate discontinuation and close monitoring (5...
متن کاملAntipsychotic treatments; focus on lurasidone
The introduction of atypical antipsychotic drugs (AAPDs), or second-generation antipsychotics, with clozapine as the prototype, has largely changed the clinicians' attitudes toward the treatment of mental illnesses including, but not limited to schizophrenia. Initially, there was optimism that AAPDs would be superior over typical antipsychotic drugs (TAPDs), or first-generation antipsychotic dr...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2012
ISSN: 1600-5368
DOI: 10.1107/s1600536812012883