Long‐term risk of endometrial cancer following postmenopausal bleeding and reassuring endometrial biopsy

Long‐term risk of endometrial cancer following postmenopausal bleeding and reassuring endometrial biopsy

INTRODUCTION Women with postmenopausal bleeding and endometrial thickness >4 mm undergo endometrial sampling to exclude endometrial cancer. The aim of this study is to investigate the relative risk of developing endometrial cancer in a prospective cohort after initial work-up for postmenopausal bleeding showing reassuring histology or insufficient sampling. MATERIAL AND METHODS All women pres...

Outpatient diagnosis of endometrial cancer in women with postmenopausal bleeding

Endometrial thickness as a test for endometrial cancer in women with postmenopausal vaginal bleeding.

OBJECTIVE To assess the value of endometrial thickness measurement as a test for endometrial cancer in postmenopausal women with vaginal bleeding (symptomatic women). DATA SOURCES We conducted a literature search using the MEDLINE database from 1991 to 1997, and the key words "vaginal ultrasonography" and "endometrial thickness measurement." The review was limited to original research reports...

Premenopausal abnormal uterine bleeding and risk of endometrial cancer

BACKGROUND Endometrial biopsies are undertaken in premenopausal women with abnormal uterine bleeding but the risk of endometrial cancer or atypical hyperplasia is unclear. OBJECTIVES To conduct a systematic literature review to establish the risk of endometrial cancer and atypical hyperplasia in premenopausal women with abnormal uterine bleeding. SEARCH STRATEGY Search of PubMed, Embase and...

Cytochrome P450 1B1 gene polymorphisms and postmenopausal endometrial cancer risk.

Estrogen unopposed by progestins is a key factor in endometrial cancer etiology. Cytochrome P450 1B1 (CYP1B1), responsible for the 4-hydroxylation of estrogen, may be important in endometrial carcinogenesis, either as a regulator of estrogen availability or as a producer of potentially genotoxic estrogen metabolites. We investigated the association of CYP1B1 genotype and endometrial cancer risk...