LKB1 Regulates Lipid Oxidation During Exercise Independently of AMPK
نویسندگان
چکیده
منابع مشابه
LKB1 Regulates Lipid Oxidation During Exercise Independently of AMPK
Lipid metabolism is important for health and insulin action, yet the fundamental process of regulating lipid metabolism during muscle contraction is incompletely understood. Here, we show that liver kinase B1 (LKB1) muscle-specific knockout (LKB1 MKO) mice display decreased fatty acid (FA) oxidation during treadmill exercise. LKB1 MKO mice also show decreased muscle SIK3 activity, increased his...
متن کاملMLK3 Phophorylates AMPK Independently of LKB1
Emerging evidence has shown that cellular energy metabolism is regulated by the AMPK and MLK3-JNK signaling pathways, but the functional link between them remains to be determined. The present study aimed to explore the crosstalk between MLK3 and AMPK. We found that both JNK and AMPK were phosphorylated at their activation sites by TNF-α, Anisomycin, H2O2 and sorbitol. Interestingly, sorbitol s...
متن کاملExercise 8: Lipid Oxidation
Lipid Molecules. Lipids are usually defined as those components that are soluble in organic solvents (such as ether, hexane or chloroform), but are insoluble in water. This group of substances includes triacylglycercols, diacylglycercols, monoacylglycercols, free fatty acids, phospholipids, sterols, caretonoids and vitamins A and D. The lipid fraction of a fatty food therefore contains a comple...
متن کاملAMPK potentiation by LKB1 isoforms
Cells must finely tune their metabolic pathways to face variations of nutrient fluxes. This dynamic maintenance of homeostasis is a fundamental requisite constraining all cellular processes. The serine/threonine kinase LKB1 is a hub of a molecular network monitoring the cellular energy charge via the phosphorylation and activation of the AMP-activated kinase (AMPK) [1]. In conditions of metabol...
متن کاملDietary glycemic index influences lipid oxidation but not muscle or liver glycogen oxidation during exercise.
The glycemic index (GI) of dietary carbohydrates influences glycogen storage in skeletal muscle and circulating nonesterified fatty acid (NEFA) concentrations. We hypothesized that diets differing only in GI would alter intramuscular lipid oxidation and glycogen usage in skeletal muscle and liver during subsequent exercise. Endurance-trained individuals (n = 9) cycled for 90 min at 70% Vo(2peak...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetes
سال: 2013
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db12-1160