Liver Disease and Hemostatic (Dys)function
نویسندگان
چکیده
منابع مشابه
Hemostatic Dysfunction in Liver Diseases.
The liver plays a central role in hemostasis, as it is the site of synthesis of most procoagulant and anticoagulant factors. It also synthesizes many fibrinolytic proteins, and is an important source of thrombopoietin. Furthermore, it is involved in clearance of many hemostatic and fibrinolytic components. Consequently, patients with a decreased synthetic capacity of the liver acquire a complex...
متن کاملLiver Disease and Hemostatic (Dys)function.
Cirrhosis presents with decreased procoagulant factors as a consequence of the impaired synthetic capacity of the liver. This was taken as evidence to explain the abnormalities of the coagulation tests prothrombin time (PT) and activated partial thromboplastin time (aPTT) and the bleeding events that occur in these patients. It was for long time (and probably is still) common practice to test p...
متن کاملHemostatic defects in end stage liver disease.
End stage liver disease results in a complex and variably severe failure of hemostasis that predisposes to abnormal bleeding. The diverse spectrum of hemostatic defects includes impaired synthesis of clotting factors, excessive fibrinolysis, disseminated intravascular coagulation, thrombocytopenia, and platelet dysfunction. Hemostasis screening tests are used to assess disease severity and moni...
متن کاملCoeliac disease and liver dysfunction.
The spectrum and pathogenesis of liver dysfunction in coeliac disease (CD) is reviewed. CD and liver disease share common risk factors, and consequences of CD may cause liver dysfunction. Liver dysfunction should be sought in CD, and its aetiology explored when abnormalities persist after gluten exclusion. CD should be excluded in patients with unexplained liver dysfunction before being labelle...
متن کاملHemostatic abnormalities and liver diseases.
Professor Eberhard F. Mammen greatly contributed to the understanding of the relationship between hemostatic abnormalities and liver diseases. The physiology of the hemostatic system is closely linked to liver function because the liver parenchymal cells produce most of the factors of the clotting and fibrinolytic systems. Acute or chronic hepatocellular diseases and hepatic failure including l...
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ژورنال
عنوان ژورنال: Seminars in Thrombosis and Hemostasis
سال: 2015
ISSN: 0094-6176,1098-9064
DOI: 10.1055/s-0035-1550440