منابع مشابه
Gastrointestinal cytoprotection by prostaglandins.
Prostaglandins (PGs) are widely distributed throughout the gastrointestinal tract and affect a variety of gastrointestinal functions. The observation that PGs of the E and A series are potent inhibitors of gastric acid secretion and that PGs, especially the E compounds, are released into the gastric lumen during vagal or gastrin stimulation suggests a possible physiological role for these agent...
متن کاملMild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins.
Several prostaglandins (PG) were found earlier to be cytoprotective for the stomach and the intestine. We now report that mild irritants, given intragastrically, are also cytoprotective by stimulating the release of PG by the stomach. Several "mild irritants," 10-20% ethanol, 0.2-0.35 M HCl, 0.05-0.075 M NaOH, 2-4% NaCl, and water at 70 degrees C, were given orally to fasted rats. Fifteen minut...
متن کاملRole of mucosal prostaglandins and DNA synthesis in gastric cytoprotection by luminal epidermal growth factor.
This study compares the effect of epidermal growth factor and prostaglandins (PGE2 or PGI2), applied topically to gastric mucosa, on gastric secretion and formation of ASA-induced gastric ulcerations in rats. Epidermal growth factor given topically in non-antisecretory doses prevented dose-dependently the formation of ASA-induced ulcers without affecting prostaglandin generation but with a sign...
متن کاملEffects of prostaglandins on renin substrate production by the liver.
1. The effects of prostaglandin (PG) E1, PGE2 and PGF2 alpha on plasma renin substrate concentration in rats and renin substrate production by perfused rat liver were investigated. 2. After bilateral nephrectomy, both plasma renin substrate concentration and renin substrate production were remarkably elevated. 3. The increase in plasma renin substrate level and production of renin substrate by ...
متن کاملGastrointestinal Cytoprotection by PPARγ Ligands
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that is known to play a central role in lipid metabolism and insulin sensitivity as well as inflammation and cell proliferation. According to the results obtained from studies on several animal models of gastrointestinal inflammation, PPARγ has been implicated in the regulation of the immune response, particularly inflam...
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ژورنال
عنوان ژورنال: Pharmacology & Therapeutics
سال: 1993
ISSN: 0163-7258
DOI: 10.1016/0163-7258(93)90067-n