Lifetime Risk from Polyurethane Covered Breast Implants: Response
نویسندگان
چکیده
منابع مشابه
Lifetime risk from polyurethane covered breast implants.
The recent article by Luu et al. (1) predicting an excess lifetime risk from polyurethane covered breast implants of 1 in 400,000 is based upon numerous questionable assumptions and cannot go unchallenged. I have listed below several of the more obvious problems with this study and its conclusions. The estimated dose of polyurethane was too high. The authors use a weight of foam in their dosage...
متن کاملA physiologically based pharmacokinetic model for 2,4-toluenediamine leached from polyurethane foam-covered breast implants.
Physiologically based pharmacokinetic (PBPK) modeling was used to assess the low-dose exposure of patients to the carcinogen 2, 4-toluenediamine (2,4-TDA) released from the degradation of the polyester urethane foam (PU) used in Meme silicone breast implants. The tissues are represented as five compartments: liver, kidney, gastrointestinal tract, slowly perfused tissues (e.g., fat), and richly ...
متن کاملLong-term safety and efficacy of polyurethane foam-covered breast implants.
BACKGROUND Polyurethane foam-covered silicone gel-filled breast implants, introduced in the 1970s, were used in more than 110,000 American women. Because of concerns about possible toxicity, they were withdrawn from the US market in 1991. These implants remain popular in many parts of the world. OBJECTIVE The goal of this study was to evaluate long-term experience with polyurethane foam-cover...
متن کاملDetection of toluenediamines in the urine of a patient with polyurethane-covered breast implants.
Breast prostheses are implanted for augmentation or during reconstructive surgery. One of the more commonly used prostheses is the polyurethane-sponge-covered silicone gel implant. Some clinicians are concerned about the safety of this product because the polyurethane foam disintegrates in vivo, and its subsequent fate is not known. Polyurethane is a polymer formed by reacting diisocyanates and...
متن کاملUrinary excretion of free toluenediamines in a patient with polyurethane-covered breast implants.
We report the detection of free 2,4-toluenediamine in urine of a patient implanted with polyurethane-covered breast implants. Samples were collected on several dates, ranging from 21 days to seven months after the insertion of the implants, and these samples all showed the presence of free 2,4-toluenediamine at a concentration of about 1 micrograms/L. The chemical was not found in a urine sampl...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1998
ISSN: 0091-6765
DOI: 10.2307/3434243