Leuprolide acetate induces structural and functional recovery of injured spinal cord in rats

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Leuprolide acetate induces structural and functional recovery of injured spinal cord in rats.

Gonadotropin-releasing hormone (GnRH) and its synthetic analog leuprolide acetate, a GnRH agonist, have neurotrophic properties. This study was designed to determine whether administration of leuprolide acetate can improve locomotor behavior, gait, micturition reflex, spinal cord morphology and the amount of microglia in the lesion epicenter after spinal cord injury in rats. Rats with spinal co...

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  Background: Spinal cord injury (SCI) is a major clinical condition and research is commonly done to find suitable treatment options. However, there are some degrees of spontaneous recovery after SCI and gender is said to be a contributing factor in recovery, but this is controversial. This study was done to compare the effects of sexual dimorphism on spontaneous recovery after spinal cord inj...

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Functional recovery assessment of spinal cord contusion model in male rats without therapeutic interventions

Introduction: Spinal cord injury (SCI) is one of the most serious clinical diseases, which not only affects the patient's physical and mental status, but its effects will be spread to family and community. After severe spinal cord injury, astrocytes of the central nervous system (CNS) become reactive astrocytes, and play the main role of glial scar formation. The scar is a major obstacle to r...

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Spinal Cord-Injured Rats

Opérant conditioning of the spinal stretch reflex or its electrical analog, the H-reflex, is a new model for exploring the mechanisms of long-term supraspinal control over spinal cord function. Primates and rats can gradually increase (HRup conditioning mode) or decrease (HRdown conditioning mode) the H-reflex when reward is based on H-reflex amplitude. An earlier study indicated that HRdown co...

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influence of sexuality in functional recovery after spinal cord injury in rats

background: spinal cord injury (sci) is a major clinical condition and research is commonly done to find suitable treatment options. however, there are some degrees of spontaneous recovery after sci and gender is said to be a contributing factor in recovery, but this is controversial. this study was done to compare the effects of sexual dimorphism on spontaneous recovery after spinal cord injur...

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ژورنال

عنوان ژورنال: Neural Regeneration Research

سال: 2015

ISSN: 1673-5374

DOI: 10.4103/1673-5374.170311