منابع مشابه
Effects of singlet oxygen on human lens crystallins in vitro.
We have recently demonstrated that singlet oxygen-mediated photooxidation can cause an increase in blue fluorescence and covalent cross-linking in bovine lens crystallins in vitro. Because these changes closely parallel modifications known to occur in human crystallins during aging and cataractogenesis, it was suggested that singlet oxygen may play an important role in these processes in vivo. ...
متن کاملSubunit composition of rabbit lens beta crystallins.
DEAE-purified rabbit beta crystallins have been studied by sedimentation on sucrose gradients ami their subunits characterized by co-electrophoresis in SDS-polyacrylamide gels. The experiments indicate that the beta crystallins isolated by DEAE-cellulose are a large family of related proteins with sedimentation velocities of about 4S. Deaggregation and denaturation of these proteins to polypept...
متن کاملOntogeny of lens crystallins in marine cephalopods.
The ontogeny of the lens crystallin antigens throughout development of three marine cephalopod embryos, Loligo vulgaris, Sepia officinalis and Octopus vulgaris has been investigated using the indirect immuno-cytochemical staining against respective homologous anti-total lens protein antiserum. The cellular mechanism of lens development appears to be the same in all species investigated and so d...
متن کاملα- and β-crystallins modulate the head group order of human lens membranes during aging.
PURPOSE To examine the physical properties of human lens cell membranes as a function of age. METHODS The environment of the phospholipid head groups in fiber cell membranes from human lenses, aged 22 to 83 years, was assessed with Laurdan and two-photon confocal microscopy. The effect of mild thermal stress on head group order was studied with lens pairs in which one intact lens was incubate...
متن کاملImmunochemical detection of glycated lens crystallins and their circulating autoantibodies in human serum during aging
PURPOSE The aim of this investigation was to exploit lens-specific glycated crystallins as an immunogen to detect human glycated crystallins and their circulating autoantibodies in human serum during aging in relation to the development of cataract. METHODS Polyclonal antibodies were produced against human total lens proteins (40-80 years) in rabbits. The specificity of the antibodies produce...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - General Subjects
سال: 2009
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2009.05.008