Lactate and lactate clearance in acute cardiac care patients

Prognostic significance of blood lactate and lactate clearance in trauma patients.

BACKGROUND Lactate has been shown to be a prognostic biomarker in trauma. Although lactate clearance has already been proposed as an intermediate endpoint in randomized trials, its precise role in trauma patients remains to be determined. METHODS Blood lactate levels and lactate clearance (LC) were calculated at admission and 2 and 4 h later in trauma patients. The association of initial bloo...

"Lactate Shift," Rather Than "Lactate Clearance," for Serial Blood Lactate Monitoring?

Gastric Dilatation-volvulus: Lactate Clearance and Prognosis

Gastric dilatation-volvulus is an acute life-threatening condition that primarily affects large-breed dogs. By definition, the initiating event of the syndrome involves an abnormal entrapment and accumulation of fluid and air within the gastric lumen that results in extreme, traumatic distention of the stomach (dilatation) and variable rotation of the stomach on its long axis (volvulus). Early ...

Is lactate clearance impaired in septic shock?

In a recent article in Critical Care, Tapia and colleagues evaluated the relationship between exogenous lactate clearance and liver perfusion in a short-term model of endotoxemic shock [1]. The authors concluded that the very low portal-hepatic vein lactate gradient was indicative of the inability of the liver to metabolize the increased lactate load. Although we believe that the authors addres...

Lactate clearance in the acutely traumatized patient.

1162 December 2012 W HEN oxygen delivery falls below a critical threshold, the anaerobic threshold, the amount of oxygen available for consumption is not able to meet the needs of cells. These imbalances result in cellular hypoxia, resulting in the failure of mitochondrial oxidative phosphorylation, and as a result energy metabolism becomes wholly dependent on anaerobic glycolysis.1 Anaerobic g...