<i>p</i>-Hydroxybenzoate Esters Enhance Mouse Contact Hypersensitivity
نویسندگان
چکیده
منابع مشابه
Regulation of contact hypersensitivity by interleukin 10
Contact hypersensitivity (CHS) responses require the participation of T cells, along with a variety of cytokines and adhesion molecules. In the classical CHS, antigen-specific T cells are recruited to a site of antigenic challenge, where they react with antigen, release cytokines, and attract other inflammatory cells. In the mouse model of CHS, this reaction is elicited in sensitized mice by ap...
متن کاملInducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
Langerhans cells (LC) form a unique subset of dendritic cells (DC) in the epidermis but so far their in vivo functions in skin immunity and tolerance could not be determined, in particular in relation to dermal DC (dDC). Here, we exploit a novel diphtheria toxin (DT) receptor (DTR)/DT-based system to achieve inducible ablation of LC without affecting the skin environment. Within 24 h after intr...
متن کاملChronic Toxoplasmosis Modulates the Induction of Contact Hypersensitivity by TNCB in Mouse Model
Mouse models of chronic toxoplasmosis and atopic dermatitis (AD) were combined to clarify the effect of opportunistic Toxoplasma gondii infection on the development of AD. AD was induced as a chronic contact hypersensitivity (CHS) with repeated challenge of 2,4,6-trinitro-1-chlorobenzene (TNCB) on the dorsal skin of mice. TNCB induced skin thickness increases in both normal and toxoplasmic mice...
متن کاملProstaglandin I2-IP signaling promotes Th1 differentiation in a mouse model of contact hypersensitivity.
PGI(2), which exerts its actions via its specific Gs-coupled I prostanoid receptor (IP), is known to be present in the lymph nodes, but its roles in acquired cutaneous immune responses remain unclear. To investigate the role of PGI(2)-IP signaling in cutaneous immune responses, we applied IP-deficient (Ptgir(-/-)) mice to contact hypersensitivity as a model of acquired immune response and found...
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ژورنال
عنوان ژورنال: Journal of Health Science
سال: 2009
ISSN: 1344-9702,1347-5207
DOI: 10.1248/jhs.55.560