Ion Mobility Collision Cross Section Compendium
نویسندگان
چکیده
منابع مشابه
Collision cross section calibrants for negative ion mode traveling wave ion mobility-mass spectrometry.
Unlike traditional drift-tube ion mobility-mass spectrometry, traveling-wave ion mobility-mass spectrometry typically requires calibration in order to generate collision cross section (CCS) values. Although this has received a significant amount of attention for positive-ion mode analysis, little attention has been paid for CCS calibration in negative ion mode. Here, we provide drift-tube CCS v...
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Introduction Carotenoids are naturally occurring pigments that function as provitamin A compounds and antioxidants. Biosynthesized in plants as the all-trans isomers, carotenoids undergo isomerization to form multiple cis isomers which have been reported to have different bioavailabilities [1]. Although C30 stationary phases are available to facilitate the chromatographic separation of caroteno...
متن کاملIon Mobility-Derived Collision Cross Section As an Additional Measure for Lipid Fingerprinting and Identification
Despite recent advances in analytical and computational chemistry, lipid identification remains a significant challenge in lipidomics. Ion-mobility spectrometry provides an accurate measure of the molecules' rotationally averaged collision cross-section (CCS) in the gas phase and is thus related to ionic shape. Here, we investigate the use of CCS as a highly specific molecular descriptor for id...
متن کاملIon Mobility Derived Collision Cross Sections to Support Metabolomics Applications
Metabolomics is a rapidly evolving analytical approach in life and health sciences. The structural elucidation of the metabolites of interest remains a major analytical challenge in the metabolomics workflow. Here, we investigate the use of ion mobility as a tool to aid metabolite identification. Ion mobility allows for the measurement of the rotationally averaged collision cross-section (CCS),...
متن کاملEvaluation of Collision Cross Section Calibrants for Structural Analysis of Lipids by Traveling Wave Ion Mobility-Mass Spectrometry
Collision cross section (CCS) measurement of lipids using traveling wave ion mobility-mass spectrometry (TWIM-MS) is of high interest to the lipidomics field. However, currently available calibrants for CCS measurement using TWIM are predominantly peptides that display quite different physical properties and gas-phase conformations from lipids, which could lead to large CCS calibration errors f...
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ژورنال
عنوان ژورنال: Analytical Chemistry
سال: 2016
ISSN: 0003-2700,1520-6882
DOI: 10.1021/acs.analchem.6b04905