Insulin-like growth factor (IGF) and IGF binding protein gene expression in multicystic renal dysplasia.
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چکیده
منابع مشابه
Insulin-like growth factor I (IGF-I) regulates IGF binding protein-5 gene expression in the brain.
Insulin-like growth factor (IGF-I) plays an important role during brain development. IGF binding protein-5 (IGFBP-5) is known to be capable of modulating IGF-I actions and is expressed in brain during development. To begin to investigate the interaction between IGF-I and IGFBP-5 in brain, we asked whether IGF-I influences the brain expression of IGFBP-5. We quantified IGFBP-5 expression in mult...
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Insulin-like growth factor (IGF)-binding proteins (IGFBPs) potently modulate the interactions of IGF-I and -II with the IGF-I receptor. Previous studies have shown that IGFBP2 gene expression is localized in astroglia, where it is anatomically and temporally coordinated with neuronal IGF-I expression during postnatal brain development. The present study shows that IGFBP5 gene expression is also...
متن کاملIdentification of insulin-like growth factor (IGF)-I and IGF-binding protein in chylous ascites.
Insulin-like growth factors (IGFs) are bound by several IGF-binding proteins (IGFBPs) that appear to regulate IGF transportation, receptor binding and action. In adult human serum, most of IGFs are bound in a 150 kDa complex which could not cross the capillary wall. We measured IGF-I and IGFBPs in chyle by radioimmunoassay and western ligand blot. The concentration of IGF-I in chyle was only 15...
متن کاملInsulin-like growth factor (IGF)-1, IGF-binding protein-3, and pancreatic cancer in male smokers.
To investigate whether insulin-like growth factor (IGF)-1 and IGF-binding protein-3 (IGFBP-3) are prospectively associated with exocrine pancreatic cancer, we conducted a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of 29,133 male Finnish smokers, aged 50-69 years. To avoid the potential influence of subclinical cancer on IGF-1 and IGFBP-3,...
متن کاملInsulin-like growth factor-I (IGF-I) and IGF binding protein-5 in Schwann cell differentiation.
Schwann cells (SCs) are the myelin producing cells of the peripheral nervous system. During development, SCs cease proliferation and differentiate into either a myelin-forming or non-myelin forming mature phenotype. We are interested in the role of insulin-like growth factor-I (IGF-I) in SC development. We have shown previously SCs proliferate in response to IGF-I in vitro. In the current study...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 1997
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v8185