Inhibitors of the Platelet Thrombin Receptor
نویسندگان
چکیده
منابع مشابه
Platelet glycocalicin. Interaction with thrombin and role as thrombin receptor of the platelet surface.
Intact human platelets contain on their outer surface a glycoprotein, glycocalicin (M, = 150,000). which is released in soluble form following platelet homogenization while glycoprotein I, which has a similar electrophoretic mobility, remains bound to the plasma membrane (Okumura, T., and Jamieson, G. A. (1976)5. Bid. Chem. 251, 5944-5949). Purified glycocalicin has now been shown to be a compe...
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Not that long ago, aspirin, heparin, and warfarin were the only available antithrombotic agents for treating cardiovascular disease patients at risk of thrombotic events. These agents are still used in several places around the world, and it is remarkable how difficult it was to discover other agents that are more effective and/or safer. Since the mid-1980s we have been witnessing an explosion ...
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Not that long ago, aspirin, heparin, and warfarin were the only available antithrombotic agents for treating cardiovascular disease patients at risk of thrombotic events. These agents are still used in several places around the world, and it is remarkable how difficult it was to discover other agents that are more effective and/or safer. Since the mid-1980s we have been witnessing an explosion ...
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Clinical manifestations of atherothrombotic disease, such as acute coronary syndromes, cerebrovascular events, and peripheral arterial disease, are major causes of mortality and morbidity worldwide. Platelet activation and aggregation are ultimately responsible for the progression and clinical presentations of atherothrombotic disease. The current standard of care, dual oral antiplatelet therap...
متن کاملSynthesis of novel peptide inhibitors of thrombin-induced platelet activation.
Inhibitors of the activation of platelet aggregation have promise as important therapeutic agents for the management of acute coronary syndrome (ACS). Platelet activation by thrombin, a serine protease, occurs by binding to and cleavage of the extracellular N-terminal domains of protease-activated receptors 1 and 4 (PAR1 and PAR4). The proteolysis of the PARs exposes new tethered ligands that t...
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ژورنال
عنوان ژورنال: Circulation
سال: 2011
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.111.021733