Inhibition ofHelicobacter pylori-induced cyclo-oxygenase-2 aggravates NSAID-caused gastric damage in Mongolian gerbils
نویسندگان
چکیده
منابع مشابه
Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbils.
Helicobacter pylori is classified by IARC/WHO as a definite human gastric carcinogen, despite "inadequate experimental evidence." To obtain direct evidence concerning this relationship, we investigated the histopathological findings of gastric mucosa using a model of H. pylori infection in Mongolian gerbils. The animals were challenged p.o. with H. pylori ATCC-43504 and sacrificed at 6, 12, and...
متن کاملOxidative DNA Damage Response in Helicobacter pylori-Infected Mongolian Gerbils
Helicobacter pylori (H. pylori) induced DNA damage which may be related to gastric cancer development. The DNA damage response coordinates DNA repair, cell-cycle transition, and apoptosis through activation of DNA damage response molecules. The damaged DNA is repaired through non-homologous end joining (NHEJ) or homologous recombination (HR). In the present study, we investigated the changes of...
متن کاملHELICOBACTER PYLORI Helicobacter pylori infection potentiates aspirin induced gastric mucosal injury in Mongolian gerbils
Background: Helicobacter pylori infection and non-steroidal anti-inflammatory drugs are two major causes of gastric ulceration but interactions between H pylori and these drugs in gastric mucosal injury are unclear. Aims: We studied the influence of experimental H pylori infection on gastric mucosal injury induced by aspirin. Subjects: Male Mongolian gerbils free of specific pathogens were used...
متن کاملProtective effect of Korean Red Ginseng extract against Helicobacter pylori-induced gastric inflammation in Mongolian gerbils
Helicobacter pylori-induced gastric inflammation includes induction of inflammatory mediators interleukin (IL)-8 and inducible nitric oxide synthase (iNOS), which are mediated by oxidant-sensitive transcription factor NF-κB. High levels of lipid peroxide (LPO) and increased activity of myeloperoxidase (MPO), a biomarker of neutrophil infiltration, are observed in H. pylori-infected gastric muco...
متن کاملHelicobacter pylori infection potentiates aspirin induced gastric mucosal injury in Mongolian gerbils.
BACKGROUND Helicobacter pylori infection and non-steroidal anti-inflammatory drugs are two major causes of gastric ulceration but interactions between H pylori and these drugs in gastric mucosal injury are unclear. AIMS We studied the influence of experimental H pylori infection on gastric mucosal injury induced by aspirin. SUBJECTS Male Mongolian gerbils free of specific pathogens were use...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2002
ISSN: 0269-2813
DOI: 10.1046/j.1365-2036.2002.01211.x