Infection with Rhinovirus Facilitates Allergen Penetration Across a Respiratory Epithelial Cell Layer

Infection with Rhinovirus Facilitates Allergen Penetration Across a Respiratory Epithelial Cell Layer.

BACKGROUND Rhinovirus infections are a major risk factor for asthma exacerbations. We sought to investigate in an in vitro system whether infection with human rhinovirus reduces the integrity and barrier function of a respiratory epithelial cell layer and thus may influence allergen penetration. METHODS We cultured the human bronchial epithelial cell line 16HBE14o- in a transwell culture syst...

Respiratory consequences of rhinovirus infection.

Rhinoviruses, a genus of the family Picornaviridae, are the cause of more than 50% of respiratory tract infections. Complications of rhinovirus infections, which include otitis media, sinusitis, exacerbations of asthma, and other pulmonary diseases, can be significant in certain populations. Reverse transcriptase-polymerase chain reaction has allowed the identification of rhinoviruses and led t...

Epithelial Cell Production of Human Human Rhinovirus Infection Induces Airway

Passage of cell-penetrating peptides across a human epithelial cell layer in vitro.

Cell barriers are essential for the maintenance and regulation of the microenvironments of the human body. Cell-penetrating peptides have simplified the delivery of bioactive cargoes across the plasma membrane. Here, the passage of three cell-penetrating peptides (transportan, the transportan analogue transportan 10, and penetratin) across a Caco-2 human colon cancer cell layer in vitro was inv...

Human Rhinovirus Group C Infection in Children with Lower Respiratory Tract Infection

Juan Pablo Scapini, Luis Pedro Flynn, Silvia Sciacaluga, Lorena Morales, and María Estela Cadario Author affi liations: Facultad de Ciencias Médicas Universidad Nacional de Rosario, Santa Fe, Argentina (J.P. Scapini); Sanatorio de Niños Rosario, Santa Fe, (L.P. Flynn; S. Sciacaluga, L. Morales); and Instituto Nacional de Enfermedades Infecciosas ANLIS “Dr Carlos Malbrán,” Buenos Aires, Argentin...