In vitro degradation of lactide-glycolide copolymers: PLA35GA30
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چکیده
منابع مشابه
In vitro release of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers.
The aims of our study were to assess the release of cytotoxic nucleoside analogs 5-fluorouracil and 2-chloro-2'-deoxyadenosine from different lactide-glycolide or lactide-caprolactone biodegradable copolymers and the effects of sterilization on this release. The polymers were sterilized either with ethylene oxide at 37 degrees C, or with gamma radiation (15 kGy, 20 kGy, or 25 kGy). The kinetics...
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Macroporous poly(lactide-co-glycolide) PLGA 75/25 foams were prepared for application in bone tissue engineering. Their in vitro degradation behaviour was followed over a 30 week period at 37 degrees C and at one of three pHs: (1) pH 5.0, which mimics the acidic environment produced by activated macrophages, (2) pH 7.4, which reproduces normal physiological conditions and (3) an intermediate pH...
متن کاملEffects of lactide monomer on the hydrolytic degradation of poly(lactide-co-glycolide) 85L/15G.
The hydrolytic degradation of oriented poly(L-lactide-co-glycolide) 85 L/15 G (PLGA 85/15) sample materials with various amounts of lactide monomer was monitored in vitro at 37 °C. The materials were manufactured from medical grade PLGA 85/15 by a two-step melt extrusion-die drawing process. Results showed that the hydrolytic degradation rate depended highly on the lactide monomer content, whic...
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We assessed the rate of release of a model nucleoside (adenosine, 5%, w/w) from nine different lactide-glycolide or lactide-caprolactone polymers. The polymer discs were eluted every second day with an artificial cerebrospinal fluid at the elution rate roughly approximating the brain extracellular fluid formation rate. Adenosine in eluate samples was assayed by HPLC. Three polymers exhibited a ...
متن کاملA novel route for the production of chitosan/poly(lactide-co-glycolide) graft copolymers for electrospinning.
Both chitosan and polylactide/polyglycolide have good biocompatibility and can be used to produce tissue engineering scaffolds for cultured cells. However the synthetic scaffolds lack groups that would facilitate their modification, whereas chitosan has extensive active amide and hydroxyl groups which would allow it to be subsequently modified for the attachment of peptides, proteins and drugs....
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ژورنال
عنوان ژورنال: Journal of Applied Polymer Science
سال: 1998
ISSN: 0021-8995,1097-4628
DOI: 10.1002/(sici)1097-4628(19980718)69:3<627::aid-app23>3.0.co;2-o