In Vitro Bioassays for Dioxin and Dixin-like Compounds.
نویسندگان
چکیده
منابع مشابه
Biomarkers and bioassays for detecting dioxin-like compounds in the marine environment.
The presence of toxic chemical contaminants in some marine organisms, including those consumed by humans, is well known. Monitoring the levels of such contaminants and their geographic and temporal variability is important for assessing and maintaining the safety of seafood and the health of the marine environment. Chemical analyses are sensitive and specific, but can be expensive and provide l...
متن کاملComparison of Two Cell-Based Assays for Screening Dioxin and Dioxin-Like Compounds in Sediments
PURPOSE: The purpose of this technical note is to report the results of studies comparing two cell-based assays as screening tools for dioxins and related compounds in sediments. The Reuber H4IIE rat hepatoma cell line and the recombinant 101L human hepatoma cell line were used to assay 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxic equivalents (TEQs) in split samples of the same sediment ext...
متن کاملRelative potencies of individual polychlorinated naphthalenes to induce dioxin-like responses in fish and mammalian in vitro bioassays.
A growing body of evidence suggests that polychlorinated naphthalenes (PCNs) may be fairly widespread environmental contaminants. This may be cause for concern because exposure to PCNs has been linked to dioxin-like biological responses in a wide variety of species. This study used three in vitro bioassays to characterize the dioxin-like potency of 18 individual PCN congeners and 1 PCN metaboli...
متن کاملInfant exposure to dioxin-like compounds in breast milk.
We used a one-compartment, first-order pharmacokinetic model to predict the infant body burden of dioxin-like compounds that results from breast-feeding. Validation testing of the model showed a good match between predictions and measurements of dioxin toxic equivalents (TEQs) in breast-fed infants, and the exercise highlighted the importance of the assumption of the rate of dissipation of TEQs...
متن کاملWorkshop on perinatal exposure to dioxin-like compounds. I. Summary.
An international workshop reviewed 20 ongoing or recently completed studies of the effects of perinatal exposures to dioxins, dibenzofurans, and PCBs on the reproductive, endocrine, neurodevelopmental, and immune systems. Many of the observed effects are consistent with these compounds acting as "environmental hormones" or endocrine disrupters. This report summarizes the conclusions and future ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Waste Management Research
سال: 2003
ISSN: 0917-0855,1883-8960
DOI: 10.3985/wmr.14.34