منابع مشابه
Immunogenetics of type 1 diabetes mellitus Azza
Introduction Type 1 diabetes mellitus (T1D) is one of the most common autoimmune diseases with several million people already affected around the globe. It can occur at any age, but is most commonly diagnosed from infancy to the late thirties. It is characterized by an absolute loss of insulin secretion, and results from an autoimmune process that destroys insulinproducing ß cells within the pa...
متن کاملImmunogenetics of type 1 diabetes.
The T-cell mediated autoimmune process that destroys pancreatic beta cells in type 1 diabetes (T1D) is a complex phenotype influenced by multiple genetic and environmental factors. Human leukocyte antigen (HLA) accounts for about half of the genetic susceptibility, through a large variety of protective and predisposing haplotypes. Other important loci associated with T1D, with much smaller effe...
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ژورنال
عنوان ژورنال: Molecular Aspects of Medicine
سال: 2015
ISSN: 0098-2997
DOI: 10.1016/j.mam.2014.12.004