IL-1 and IL-1 regulatory pathways in cancer progression and therapy
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چکیده
منابع مشابه
Expression of IGF-1, IL-27 and IL-35 Receptors in Adjuvant Induced Rheumatoid Arthritis Model
Background: IGF-1 and certain other cytokines have been shown to exert inflammatory/anti-inflammatory roles in chronic joint diseases. Objective: To assess the effect of IGF-1, IL-27 and IL-35, their interaction and their receptor expression in a rheumatoid arthritis model. Methods: Freund’s adjuvant-induced chronic joint inflammation was operated on 160 male rats. Animals were divided into his...
متن کاملIL-1 Receptor-Associated Kinase Signaling and Its Role in Inflammation, Cancer Progression, and Therapy Resistance
Chronic inflammation has long been associated with the development of cancer. Among the various signaling pathways within cancer cells that can incite the expression of inflammatory molecules are those that activate IL-1 receptor-associated kinases (IRAK). The IRAK family is comprised of four family members, IRAK-1, IRAK-2, IRAK-3 (also known as IRAK-M), and IRAK-4, which play important roles i...
متن کاملthe effect of il-22 and il-28 in induction of type 1 regulatory t (tr1) cells.
cytokines have been introduced as critical inducers in the development of th subpopulations.cytokines like il-10 are involved in inducing regulatory t cells such as type 1 regulatory t (tr1) cells cells. il-22 is a member of il-10 family of cytokines, and il-28a is a member of ifn-γ family. in this study, cord blood mononuclear cells (cbmc) from normal healthy individuals were isolated by ficol...
متن کاملبررسی غلظت IL-1? و IL-6 و IL-8 و TNF-? در کنسانتره های پلاکتی
Background: As increase of cytokines (like IL-1 , IL-6 , IL-8 and TNF- ) in platelet concentrates (PCs) during storage are involved in Febrile Non Hemolytic Transfusion Reactions (FNHTRs) after Platelet transfusion, the aim of this study was the survey of these cytokines level in PCs produced in Tehran Blood Center. Materials and Methods: This study proposed to determine if WBC reduction in P...
متن کاملTargeting inflammasome/IL-1 pathways for cancer immunotherapy
The inflammatory microenvironment has been shown to play important roles in various stages of tumor development including initiation, growth, and metastasis. The inflammasome is a critical innate immune pathway for the production of active IL-1β, a potent inflammatory cytokine. Although inflammasomes are essential for host defense against pathogens and contribute to autoimmune diseases, their r...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2017
ISSN: 0105-2896
DOI: 10.1111/imr.12614