Idiopathic orthostatic hypotension, midodrine, and anaesthesia

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Efficacy of single or combined midodrine and pyridostigmine in orthostatic hypotension.

OBJECTIVE To evaluate the long-term (for up to 3 months) efficacy and safety of single or combined therapy with midodrine and pyridostigmine for neurogenic orthostatic hypotension (OH). METHODS This was a randomized, open-label clinical trial. In total, 87 patients with symptomatic neurogenic OH were enrolled and randomized to receive 1 of 3 treatments: midodrine only, pyridostigmine only, or...

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Hemodynamic effects of midodrine after spaceflight in astronauts without orthostatic hypotension.

INTRODUCTION Orthostatic hypotension and presyncope are common and potentially serious risks for astronauts returning from space. Susceptible subjects fail to generate an adequate adrenergic response to upright posture. The alpha-1 adrenergic agonist, midodrine, may be an effective countermeasure. We tested the hypothesis that midodrine would have no negative hemodynamic effect on healthy astro...

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Orthostatic hypotension.

A 29-year-old white woman (weight, 1211b; height, 5 ft 6 in.) was referred to the Hypertension Unit of Massachusetts General Hospital in December 1984. She had been athletic and apparently in excellent health until September 1979 when she contracted an upper respiratory tract infection associated with wheezing. She was treated with prednisone for 5 days with resolution of the symptoms but later...

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Blood pressure during supine exercise in idiopathic orthostatic hypotension.

IDIOPATHIC orthostatie hypotension is characterized by an excessive fall in arterial blood pressure on standing and by other manifestations of an extensive loss of autonomic nervous function. In the present study the arterial blood pressure was measured in seven patients with orthostatic hypotension during the performance of mild leg exercise in the supine position. The finding of a pronounced ...

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Localization of lesion in patients with idiopathic orthostatic hypotension.

The different components of the baroreceptor reflex were studied in 8 patients with idiopathic orthostatic hypotension. The reflex arc was interrupted in all patients and the lesion was most probably localized to the efferent sympathetic fibres. This was suggested by the negative cold pressor test, the absence of pressor response to mental arithmetic, and loss or reflex sweating. Selective spar...

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ژورنال

عنوان ژورنال: Canadian Journal of Anaesthesia

سال: 1991

ISSN: 0832-610X,1496-8975

DOI: 10.1007/bf03007588