Identification of HLA-DP polymorphism with DP alpha and DP beta probes and monoclonal antibodies: correlation with primed lymphocyte typing.
نویسندگان
چکیده
منابع مشابه
Structural requirements for pairing of alpha and beta chains in HLA-DR and HLA-DP molecules
To test for the assembly of human MHC class II molecules having an alpha chain from one isotype (HLA-DR, -DQ, or -DP) and the beta chain of another (mixed isotypic pairs), murine fibroblasts were transfected with expressible cDNAs encoding the different class II alpha and beta chains. A rapid and efficient transient transfection system was developed using a polyoma virus-based vector. Typically...
متن کاملHLA-DP antibodies before and after renal transplantation.
Human leukocyte antigen (HLA)-DP is considered a target for humoral immune response in clinical transplantation. This study analyses the incidence of HLA-DP antibodies in renal patients. Development and epitope specificity of donor-specific antibodies (DSA) and non-DSA (NDSA) were examined. Pre- and posttransplant sera of 338 patients were screened for HLA-DP antibodies using the luminex single...
متن کاملCorrelation of HLA-DP/DQ polymorphisms with transplant etiologies and prognosis in liver transplant recipients
Previous study has identified that the genetic variants in the human leukocyte antigen (HLA)-DP/DQ region were strongly associated with hepatitis B virus (HBV) infection. But their roles in liver function recovery after hepatic transplantation were still obscure. This study aimed to investigate whether HLA-DP/DQ polymorphisms were associated with post-transplant etiologies and prognosis in Chin...
متن کاملHLA class II regulation and structure. Analysis with HLA-DR3 and HLA-DP point mutants
Point mutations that affect HLA-DR structure or expression have not previously been described. In the present study, we isolated such mutants by immunoselection of an ethyl methanesulfonate-mutagenized HLA-DR3 cell line with an anti-HLA-DR3 monoclonal antibody, 16.23. To facilitate analysis, we used a parent cell line with a preexisting deletion of one haplotype encompassing DR and DQ alpha and...
متن کاملOn Dp-Dp+4 systems, QCD dual and phenomenology
D4-D8 and D3-D7 systems are studied and a possible holographic dual of large N QCD (SU(N) gauge fields and fundamental quarks) is sought. A candidate system is found, for which however no explicit solution is available. Susy is broken by having a D7 − D̄7 condensing to a D5. The mechanism for supersymmetry breaking is then used to try to construct a Standard Model embedding. One can either obtai...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1987
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.84.13.4596