How stomatin stops ASIC3 gating
نویسندگان
چکیده
منابع مشابه
The effects of acid-sensing ion channel ASIC3 and stomatin-like proteins on mechanosensation and nociception
Transformation of mechanical energy into electrical signals in mechanosensory neurons is essential for mechanosensation and nociception. This transformation occurs via sensory transduction channels that are activated by external force. Recent genetic and electrophysiological studies in Caenorhabditis elegans have directly shown that the degenerin/epithelial sodium channel (DEG/ENaC) ion channel...
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Acid-sensing ion channels (ASICs) and their interaction partners of the stomatin family have all been implicated in sensory transduction. Single gene deletion of asic3, asic2, stomatin, or stoml3 all result in deficits in the mechanosensitivity of distinct cutaneous afferents in the mouse. Here, we generated asic3(-/-):stomatin(-/-), asic3(-/-):stoml3(-/-) and asic2(-/-):stomatin(-/-) double mu...
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Stomatin proteins oligomerize at membranes and have been implicated in ion channel regulation and membrane trafficking. To obtain mechanistic insights into their function, we determined three crystal structures of the conserved stomatin domain of mouse stomatin that assembles into a banana-shaped dimer. We show that dimerization is crucial for the repression of acid-sensing ion channel 3 (ASIC3...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2020
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.202012574