How Does Multistep Tumorigenesis Really Proceed?
نویسندگان
چکیده
منابع مشابه
How does multistep tumorigenesis really proceed?
Identifying the cancer cells-of-origin is of great interest, as it holds the potential to elucidate biologic mechanisms inherent in the normal cell state that have been co-opted to drive the oncogenic cell state. An emerging concept, proposed here, states that cancer stem cells, key players in cancer initiation and metastasis, arise when transit-amplifying cells with mutant genomes dedifferenti...
متن کاملMouse models for multistep tumorigenesis.
The mouse is an ideal model system for studying the molecular mechanisms underlying the pathogenesis of human cancer. The generation of transgenic and gene-knockout mice has been instrumental in determining the role of major determinants in this process, such as oncogenes and tumor-suppressor genes. In the past few years, modeling cancer in the mouse has increased in its complexity, allowing in...
متن کاملHow Much Does Industry Matter, Really?
In this paper, we examine the importance of year, industry, corporate-parent, and businessspecific effects on the profitability of U.S. public corporations within specific 4-digit SIC categories. Our results indicate that year, industry, corporate-parent, and business-specific effects account for 2 percent, 19 percent, 4 percent, and 32 percent, respectively, of the aggregate variance in profit...
متن کاملHow Much Does Complexity Really Cost?
Companies can increase their EBIT by 3 to 5 percent on average—if they make systemat ic, cross-functional improvements based on transparent complexity costs. Uncontrolled complexity is choking profi ts at too many companies. Because its effects are siloed in separate departments, management often fails to see the relationship between complexity and costs across the value chain. Yet a recent A.T...
متن کاملMultistep tumorigenesis in peripheral T cell lymphoma.
Peripheral T cell lymphomas (PTCL) are classified as mature T cell neoplasms. However, several new findings support the notion that premalignant cells arise in the immature stage of hematopoietic differentiation, and subsequently evolve into full-blown T-lineage tumor cells. Acquisition of (Ten-Eleven Translocation 2) TET2 mutations may be an important event for the establishment of premalignan...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Discovery
سال: 2015
ISSN: 2159-8274,2159-8290
DOI: 10.1158/2159-8290.cd-14-0788