منابع مشابه
Prostate cancer-derived angiogenin stimulates the invasion of prostate fibroblasts
Prostate fibroblasts promote prostate cancer progression by secreting factors that enhance tumour growth and induce the migration and invasion of prostate cancer cells. Considering the role of fibroblasts in cancer progression, we hypothesized that prostate cancer cells recruit these cells to their vicinity, where they are most directly available to influence cancer cell behaviour. To test this...
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متن کاملThe death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion.
The death receptor CD95 promotes apoptosis through well-defined signalling pathways. In colorectal cancer cells, CD95 primarily stimulates migration and invasion through pathways that are incompletely understood. Here, we identify a new CD95-activated tyrosine kinase pathway that is essential for CD95-stimulated tumour cell invasion. We show that CD95 promotes Tyr 783 phosphorylation of phospho...
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Glioblastoma is a disease characterized by rapid invasive tumour growth. Studies on the proapoptotic CD95/CD95L signalling pathway recently suggested a significant contribution of CD95 signalling towards the high degree of motility in glioma cells. Apogenix has developed APG101, a clinical phase II compound designed to bind and neutralize CD95L, and thus to interfere with CD95/CD95L-based signa...
متن کاملThe death receptor CD95 activates the cofilin pathway to stimulate tumor cell invasion
Both referees agree that your results are novel, important and of broad interest. However, both have serious concerns about the strength of the conclusions you are able to draw from your current experiments and ask that you undertake work to improve the evidence presented. Both agree that your final conclusion, that CD95 stimulation activates PLCgamma1 via PDGFR, is not yet well supported by th...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2011
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.10.22.18290