HIGH-TITER COLD AGGLUTININ-INDUCED HEMOLYSIS OF RED BLOOD CELLS
نویسندگان
چکیده
منابع مشابه
The variability of hemolysis in the cold agglutinin syndrome.
The amount of lysis effected by cold agglutinins is directly related to the ability of the antibody to initiate complement activation. This ability is modified by the concentration of antibody, its thermal amplitude (the highest temperature at which the antibody will react with the cell), the degree to which antibody fixation is modified by the presence of complement components (particularly C3...
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Since the discovery of the composition and structure of the mammalian cell membrane, biologists have had a clearer understanding of how substances enter and exit the cell's interior. The selectively permeable nature of the cell membrane allows the movement of some solutes and prevents the movement of others. This has important consequences for cell volume and the integrity of the cell and, as a...
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Hemolysis has been reported in red blood cells (RBCs) that have undergone leukocyte-reduction filtration. This study investigated whether the age of RBCs or the filter type affected hemolysis. One hundred eighty units of RBCs (adenine-saline added) were leukocyte-reduced by filtration. At each of the 6 weeks of shelf life, 10 units were filtered with the "BPF4" filter, 10 units with the "Purece...
متن کاملMeasurement of the third component of complement bound to red blood cells in patients with the cold agglutinin syndrome.
The amount of the third component of complement (C3) bound to red cells of patients with the cold agglutinin syndrome was determined by a quantitative assay, measuring the fixation of the first component of complement by anti-C3. Abrupt reduction in the serum concentration of cold agglutinin by plasmapheresis markedly decreased the hemolytic rate, but the amount of C3 bound to circulating cells...
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ژورنال
عنوان ژورنال: Japanese Journal of Transfusion and Cell Therapy
سال: 2018
ISSN: 1881-3011,1883-0625
DOI: 10.3925/jjtc.64.1