High-Performance Magnetic-core Coils for Targeted Rodent Brain Stimulations

Objective and Impact Statement . There is a need to develop rodent coils capable of targeted brain stimulation for treating neuropsychiatric disorders understanding mechanisms. We describe novel coil design improve the focality stimulations in small brains. Introduction Transcranial magnetic (TMS) becoming increasingly important Preclinical studies permit invasive manipulations are essential mechanistic TMS effects explorations therapeutic outcomes disease models. However, existing tools lack stimulations. Notably, there has been limited fundamental research on developing focal at deep regions animals like rodents. Methods In this study, ferromagnetic cores added angle-tuned enhance performance regarding penetration depth focality. Numerical simulations experimental electric field measurements were conducted optimize design. Results The proposed system demonstrated significantly smaller spot size enhanced decay rate comparison coils. Adding core reduces energy requirements up 60% stimulation. simulated results validated with demonstration suprathreshold limb excitation through motor cortex activation. Conclusion newly developed suitable due their improved rate.