Heterochirality and Halogenation Control Phe-Phe Hierarchical Assembly
نویسندگان
چکیده
منابع مشابه
The Phe-Phe Motif for Peptide Self-Assembly in Nanomedicine.
Since its discovery, the Phe-Phe motif has gained in popularity as a minimalist building block to drive the self-assembly of short peptides and their analogues into nanostructures and hydrogels. Molecules based on the Phe-Phe motif have found a range of applications in nanomedicine, from drug delivery and biomaterials to new therapeutic paradigms. Here we discuss the various production methods ...
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Biochemical analysis has shown the pond snail Lymnaea stagnalis to contain 2 main classes of Phe-Met-Arg-Phe-NH, (FMRFamide)-like neuropeptides: the tetrapeptides FMRFamide and Phe-Leu-Arg-Phe-NH, (FLRFamide), and the heptapeptides Gly-Asp-Pro-Phe-Leu-Arg-Phe-NH, (GDPFLRFamide) and Ser-Asp-Pro-Phe-Leu-Arg-Phe-NH, (SDPFFRFamide). By genomic mapping and DNA sequencing, we show here that the GDP/S...
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To investigate the chemical conformations and functions of the -Phe-Phe-Val- or -Phe-Phe- sequences contained in the Alzheimer's disease related beta-amyloid peptide, a series of mini parallel double-stranded peptides conjugated with two peptide residues to one spacer were designed and prepared. The structure of the compounds was elucidated by circular dichroism (CD) spectrum and NMR two dimens...
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Download curonidation is an important pathway in the metabolism of nicotine, with previous studies suggesting 22% of urinary nicotine metabolites are in the form of glucuronidated compounds. Recent in vitro studve suggested that the UDP-glucuronosyltransferases (UGT) 2B10 and 2B17 play major roles in nicotine onidation with polymorphisms in both enzymes shown to significantly alter the levels o...
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ژورنال
عنوان ژورنال: ACS Nano
سال: 2020
ISSN: 1936-0851,1936-086X
DOI: 10.1021/acsnano.0c06041