Heart transplant rejection pathology
نویسندگان
چکیده
Background/Aim. Heart transplantation is the most effective way to treat patients in terminal stage of heart failure. Endomyocardial biopsy has proven be a safe and appropriate technique, with little sampling error, remains, this day, one commonly used methods for diagnosing acute rejection. In 1990, International Society Lung Transplantation defined standardized system grading severity transplant rejection regarding endomyocardial histopathological analysis. The aim study was assess morphological, immunohistochemical, immunofluorescent markers cell- antibody-mediated transplants monitored during 2020. Methods. From 31 transplanted at Clinic Cardiac Surgery University Clinical Center Serbia, material obtained, then processed analyzed Institute Pathology Faculty Medicine, Belgrade. Results. average Transplant Rejection Score (TRS) value 0.42. Spearman's correlation test did not show statistically significant relationship between TRS difference ejection fraction values three twelve months after transplantation. Conclusion. mean obtained suggests dominant cell-mediated graft
منابع مشابه
Laboratory Tests for Heart Transplant Rejection
PLEASE NOTE: Contracts exclude from coverage, among other things, services or procedures that are considered investigational or cosmetic. Providers may bill members for services or procedures that are considered investigational or cosmetic. Providers are encouraged to inform members before rendering such services that the members are likely to be financially responsible for the cost of these se...
متن کاملThe CardioWest total artificial heart for chronic heart transplant rejection.
Mechanical circulatory support has been used to treat graft failure after heart transplantation, but in patients who needed mechanical circulatory support because of chronic rejection, we have suffered from the treatment because its outcome was catastrophic. Multiple organ failure was often caused by the addition of or increase in immunosuppressive medications, and it is known as a cause of the...
متن کاملMicroRNAs as non-invasive biomarkers of heart transplant rejection.
AIM Rejection is one of the major causes of late cardiac allograft failure and at present can only be diagnosed by invasive endomyocardial biopsies. We sought to determine whether microRNA profiling could serve as a non-invasive biomarker of cardiac allograft rejection. METHODS We included 113 heart transplant recipients from four referral French institutions (test cohort, n = 60, validation ...
متن کاملFear of rejection--monitoring the heart-transplant recipient.
Among patients undergoing heart transplantation, a fundamental clinical concern is the risk of rejection of the new organ. Although modern immunosuppressive regimens have reduced the incidence of rejection substantially, about one quarter of recipients will still have a rejection episode requiring treatment during the first year after transplantation.1 Acute rejection is the cause of 12% of dea...
متن کاملEcho rejection score: new echocardiographic approach to diagnosis of heart transplant rejection.
OBJECTIVE The gold standard test in the diagnosis of heart transplant rejection is right ventricular (RV) myocardial biopsy, which is an invasive, time-consuming, expensive method. In an effort to find a reliable method to minimise the sequential use of myocardial biopsy, we assessed the main echocardiographic indices for the detection of allograft rejection. MATERIALS AND METHODS Fifty myoca...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Vojnosanitetski Pregled
سال: 2022
ISSN: ['2406-0720', '0042-8450']
DOI: https://doi.org/10.2298/vsp210716083s