Grape and Grape-Based Product Polyphenols: A Systematic Review of Health Properties, Bioavailability, and Gut Microbiota Interactions

Grapevine-derived products have been widely studied for their reported benefits, especially those related to the prevention of cardiovascular diseases. However, in recent years, interest study grapes and non-fermented derivatives (grape juices) has gained prominence over well-known red wine, since grape juices seem be beneficial effects associated with Mediterranean diet, consequently presence phenolic compounds. The focus this systematic review was profiles grape, juice, as well possible consumption on human microbiota through a literature review. PubMed Scopus were accessed during April 2021 PRISMA methodological protocol followed. To best our knowledge, is first time that methodology applied knowledge. This allowed scientific description of: (a) comparison between derived source compounds, (b) great possibilities working new line investigation based synergy polyphenol microbiota, (c) urgent need strategies improve bioavailability these