Genome-wide mechanisms of nuclear receptor action

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Genome-wide mechanisms of nuclear receptor action.

Nuclear receptors are involved in a myriad of physiological processes, responding to ligands and binding to DNA at sequence-specific cis-regulatory elements. This binding occurs in the context of chromatin, a critical factor in regulating eukaryotic transcription. Recent high-throughput assays have examined nuclear receptor action genome-wide, advancing our understanding of receptor binding to ...

متن کامل

Genome-wide approaches for identification of nuclear receptor target genes

Large-scale genomics analyses have grown by leaps and bounds with the rapid advances in high throughput DNA sequencing and synthesis techniques. Nuclear receptor signaling is ideally suited to genomics studies because receptors function as ligand-regulated gene switches. This review will survey the strengths and limitations of three major classes of high throughput techniques widely used in the...

متن کامل

Molecular Mechanisms of Glucocorticoid Receptor Action

Glucocorticoids are the most effective therapy for the treatment of many chronic infl ammatory diseases such as asthma and infl ammatory bowel disease (Ito et al., 2006a). In contrast to the situation in asthma, chronic obstructive pulmonary disease (COPD), a common and debilitating chronic infl ammatory disease of the lung, is glucocorticoid insensitive (Barnes, 2000a, b; Culpitt et al., 2003)...

متن کامل

Genome-wide studies of nuclear receptors in cell fate decisions.

Nuclear receptors (NRs) are important mediators of the information encoded in the chemical structure of its corresponding ligand, as they interpret such information in the context of the cell identity and physiological status and convert it into sequential transcription regulatory events. At the cell level this can result in temporally coordinated processes such as cell fate transitions, which ...

متن کامل

The Different Mechanisms of Action Potential Propagation in the Heart

It was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. Some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (AP). It seems that some other types of mechanisms must be involved in AP propagation. In this article, we...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Trends in Endocrinology & Metabolism

سال: 2010

ISSN: 1043-2760

DOI: 10.1016/j.tem.2009.08.006