Genetic Basis of Steroid Resistant Nephrotic Syndrome
نویسندگان
چکیده
منابع مشابه
The Genetic Basis of Steroid-resistant Nephrotic Syndrome
Nephrotic syndrome (NS) is characterized by massive proteinuria (over 40 mg/m2/day) leading to hypoalbuminemia and edema. The prevalence in the general population is estimated to be 16/100,000 children (1). Whereas most children with NS would achieve remission within 4 weeks of daily steroid therapy, 10-20% remain steroid-resistant (SRNS). At least 50% of patients with SRNS, presenting in child...
متن کاملSteroid Resistant Nephrotic Syndrome
Minimal Change disease (MCD) is the most common cause of Nephrotic Syndrome (NS) in children accounting for 70 to 90% of cases under the age of 10 years and 50% in older children.In adults MCD is found in 10 to 15% of cases with primary nephrotic syndrome. Most patients with MCD remit with steroids.1 Remission is defined as absence of proteinuria (urine albumin nil or trace on 3 conservative da...
متن کاملChildren with Steroid-resistant Nephrotic Syndrome: a Single-Center Study
Background and Aim: Steroid-resistant nephrotic syndrome (SRNS) accounts for 10%-20% of all cases of idiopathic nephrotic syndrome. These patients are at risk of developing end-stage renal disease. The aim of this study was to determine the demographic characteristics, renal biopsy findings, response to immunosuppressive treatment, and prognosis in pediatric patients with SRNS.Materials and Met...
متن کاملTreatment of steroid-resistant pediatric nephrotic syndrome
Children who suffer from steroid-resistant nephrotic syndrome (SRNS) require aggressive treatment to achieve remission. When intravenous high-dose methylprednisolone fails, calcineurin inhibitors, such as cyclosporine and tacrolimus, are used as the first line of treatment. A significant number of patients with SRNS progress to end-stage renal disease if remission is not achieved. For these chi...
متن کاملSteroid resistant nephrotic syndrome: role of histopathology.
This study was conducted to (1) see the histopathological distribution of different subtypes in steroid resistant nephrotic syndrome (SRNS) and (2) compare the clinical, biochemical parameters and outcome between Minimal Change Disease (MCD) with non-MCD subtypes in response to immunosuppressive therapy. A retrospective analysis was done of data on all biopsy proven children with idiopathic SRN...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Childhood Kidney Diseases
سال: 2019
ISSN: 2384-0242,2384-0250
DOI: 10.3339/jkspn.2019.23.2.86