Gefitinib in Non Small Cell Lung Cancer
نویسندگان
چکیده
منابع مشابه
Gefitinib in Non Small Cell Lung Cancer
Gefitinib is an oral, reversible, tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR) that plays a key role in the biology of non small cell lung cancer (NSCLC). Phase I studies indicated that the recommended dose of gefitinib was 250 mg/day. Rash, diarrhea, and nausea were the most common adverse events. The positive results obtained in early phase 2 clinical trials with gefit...
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IMPORTANCE OF THE FIELD The epidermal growth factor receptor (EGFR) is a leading target for treatment of non-small-cell lung cancer (NSCLC). Recent trials of the small-molecule EGFR inhibitor gefitinib have now more clearly defined indications for usage, and clinical and molecular factors predictive of benefit. AREAS COVERED IN THIS REVIEW A systematic search of the literature (Medline, ASCO,...
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Gefitinib is approved as monotherapy for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) in patients who have failed prior platinum-based treatment and docetaxel chemotherapy. Its efficacy when compared to standard treatment and best supportive care is unproven. Common drug-related adverse effects include gastrointestinal and skin disorders. Rare but serious d...
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Authors: R. van Puijenbroek, L. Bosquée, A-P. Meert, D. Schallier, J-C. Goeminne, G. Tits, P. Collard, K. Nackaerts, J-L Canon, F. Duplaquet, D. Galdermans, P. Germonpré, M-A. Azerad, G. Vandenhoven, J. De Greve, J. Vansteenkiste. Affiliations: Univ. Hospital, Catholic University, Leuven Citadelle Hospital, Liège Jules Bordet Institute, Brussels Univ. Hopsital VUB, Brussels St-Elisabeth Hospita...
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Objective(s): Lymph node metastases are the most significant prognostic factor in localized non-small cell lung cancer (NSCLC). Identification of the first nodal drainage site (sentinel node) may improve detection of metastatic nodes. Extended surgeries, such as lobectomy or pneumonectomy with lymph node dissection, are among the therapeutic options of higher acceptab...
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ژورنال
عنوان ژورنال: Journal of Biomedicine and Biotechnology
سال: 2011
ISSN: 1110-7243,1110-7251
DOI: 10.1155/2011/815269