Formulation of Boron Encapsulated Smart Nanocapsules for Targeted Drug Delivery to the Brain
نویسندگان
چکیده
Drug delivery through the Blood–Brain Barrier (BBB) represents a significant challenge. Despite current strategies to circumvent BBB, nanotechnology offers unprecedented opportunities for combining selective delivery, improved bioavailability, drug protection, and enhanced pharmacokinetics profiles. Chitosan nanocarriers allow more efficacious strategy at cellular sub-cellular levels. Boron Neutron Capture Therapy (BNCT) is targeted chemo-radiotherapeutic technique that allows depletion of cancer cells by means tagging with 10B, followed irradiation low-energy neutrons. Consequently, combination polymer-based nanodelivery system enclosing an effective BNCT pharmacophore can potentially lead load beyond BBB. In this work, synthesized novel boronated agents based on carborane-functionalized Delocalized Lipophilic Cations (DLCs) are assessed safety targeting tumour cells. The compounds then encapsulated in constituted chitosan promote permeability Additionally, was used polypyrrole form smart composite nanocapsule, which expected release its variations pH. Results indicate achievement boron via carboranyl DLCs. Finally, preliminary cell studies no toxicity detected nanocapsules, further enhancing viability as potential vehicle brain tumours.
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ژورنال
عنوان ژورنال: Applied sciences
سال: 2021
ISSN: ['2076-3417']
DOI: https://doi.org/10.3390/app112210738