Flumazenil reverses diazepam-induced neonatal apnoea and hypotonia
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چکیده
منابع مشابه
Antagonism of diazepam sedation by flumazenil.
Forty adult patients undergoing elective surgery, anaesthetized with diazepam, alfentanil and nitrous oxide in oxygen, and paralysed with atracurium were given flumazenil or placebo i.v. in a double-blind randomized study to assess the efficacy of flumazenil. Awake state, heart rate, arterial pressure, rate of ventilation and arterial blood-gas values were measured at 0, 5, 30, 120 and 240 min ...
متن کاملFlumazenil-induced ballism.
Flumazenil, an imidazobenzodiazepine, is the first benzodiazepine antagonist and is being used to reverse the adverse pharmacological effects of benzodiazepine. There have been a few reports on the central nevous system side effects with its use. We report a patient with generalized ballism following administration of flumazenil. The mechanism through which flumazenil induced this symptom is un...
متن کاملZellweger syndrome: A cause of neonatal hypotonia and seizures.
Zellweger syndrome, a paradigm of human peroxisomal disorders is characterized by dysmorphic features, hypotonia, severe neuro-developmental delay, hepatomegaly, renal cysts, sensorineural deafness and retinal dysfunction. This is a case report of a baby boy born with facial dysmorphism, profound hypotonia, seizures, and hepatomegaly. The diagnosis was not evident initially but only later when ...
متن کاملFlumazenil attenuates development of tolerance to diazepam after chronic treatment of mice with either isoflurane or diazepam.
UNLABELLED In an effort to clarify the mechanism of action of isoflurane, we studied the effect of flumazenil on mice chronically treated with isoflurane or diazepam. Mice were pretreated with diazepam, isoflurane, or saline, with and without flumazenil. After 2 wk, responses to isoflurane and diazepam were assessed, and central benzodiazepine receptor (CBR) binding characteristics were assayed...
متن کاملEffects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance.
BACKGROUND Post-ischaemic benzodiazepine administration is neuroprotective, but chronic administration of benzodiazepines can induce tolerance, such that the neuroprotective effect may be reduced. This study investigated whether benzodiazepine tolerance can worsen ischaemic injury and whether neuroprotection by post-ischaemic benzodiazepine administration is affected by benzodiazepine tolerance...
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ژورنال
عنوان ژورنال: European Journal of Pediatrics
سال: 1993
ISSN: 0340-6199,1432-1076
DOI: 10.1007/bf01955914