منابع مشابه
Finding Frameworks Hot Spots in Pattern Languages
An important issue that contributes to the complexity of object-oriented framework development is the identification of its hot spots, i.e., the framework parts that must be kept flexible, as they are specific of individual systems. A process for identification of hot spots in an analysis pattern language is proposed. Several types of hot spots are identifiable from information presented in the...
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Five insulin dependent diabetic patients are reported on who had a few small retinal cotton-wool spots or 'soft exudates' either totally isolated or associated with fewer than 10 microaneurysms. These observations suggest that cotton-wool spots may be an early finding in diabetic retinopathy. Significant biological abnormalities in these patients were high levels of glycosylated haemoglobin and...
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A key step in experiments using DNA microarrays is locating the thousands of individual spots in a scanned array image. Each spot provides quantitative information about a distinct DNA sequence, so it is imperative that spots be found and quantitated accurately. Spot finding is complicated by variations in the positions and sizes of spots and by the presence of artifacts and background noise in...
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A protein interface can be as "wet" as a protein surface in terms of the number of immobilized water molecules. This important water information has not been explicitly taken by computational methods to model and identify protein binding hot spots, overlooking the water role in forming interface hydrogen bonds and in filing cavities. Hot spot residues are usually clustered at the core of the pr...
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Fas (CD95, APO-1, TNFRSF6) is a TNF receptor superfamily member that directly triggers apoptosis and contributes to the maintenance of lymphocyte homeostasis and prevention of autoimmunity. Although FADD and caspase-8 have been identified as key intracellular mediators of Fas signaling, it is not clear how recruitment of these proteins to the Fas death domain leads to activation of caspase-8 in...
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ژورنال
عنوان ژورنال: Nature
سال: 2011
ISSN: 0028-0836,1476-4687
DOI: 10.1038/469166a