Familial predisposition to cardiovascular disease and death in patients with an out-of-hospital cardiac arrest

Abstract Funding Acknowledgements Type of funding sources: Public hospital(s). Main source(s): Rigshospitalet Introduction Familial predisposition to cardiovascular disease (CVD) and death among patients with out-of-hospital cardiac arrest (OHCA), is sparsely described in current literature. A higher rate events first-degree relatives might imply an increased risk future could provide vital improvements prevention sudden death. Therefore, investigation CVD family OHCA-victims needed. Purpose Determine familial OHCA. Methods This study used the nationwide Danish Cardiac Arrest Registry identify all OHCA (probands) presumed origin from 2001-2014 <70 years age at time First-degree were identified using Family Relations Database. We included probands least one identifiable relative. Date was defined as index for relatives. The stratified groups (0-18, 19-29, 30-49, 50-69 OHCA) assessed each group. diagnosis any ICD-10 I00-I51 code (hypertension (I10-I14) excluded) CVD-death being main cause. Probands matched a background population (1:4) on sex. similarly those probands. Rates compared population. Results 5,443 (75% male, median 51 years) 16,260 relatives; 10,207 parents (48.2% fathers, 71 6,053 full siblings (52.7% brothers, 47.2 years). Parents had (27.5% vs. 21.9%), mortality (51.4% 38.4%) more often caused by (39.9% 34.1%) (p<0.001 all). Stratified groups, 30-49 their corresponding (bar diagram fig.1). Siblings also (4.9% 2.9%, p<0.001), (3.5% 2.0%, (16.9% 12.4%, p=0.19) group, both fig.2). Conclusion prevalent These results indicate that, important factors family.