Experimental research models for skeletal muscle contraction

Chemo-mechanical model for skeletal muscle contraction

Generation of force in skeletal muscle tissue depends on both chemical and mechanical phenomena. In this work, considering the kinetics of cross bridges, a one dimensional model has been proposed for predicting the isometric force according to the intracellular calcium ion distribution. Introduction The different ways of skeletal muscle activation lead to the formation of cross bridges (XB) acc...

Excitation-contraction coupling in skeletal muscle.

Metabolic Inhibition During Rat Skeletal Muscle Contraction

Our previous studies in rat skeletal muscle have determined that neural constriction of large arterioles, which regulate blood flow and peripheral resistance, is mediated by al-adrenoceptors, whereas small arterioles, which determine effective capillary density, depend on £V2receptors. During physical exercise, metabolic vasodilators from contracting skeletal muscle oppose neural vasoconstricti...

Biomimetic model of skeletal muscle isometric contraction: II. A phenomenological model of the skeletal muscle excitation-contraction coupling process

This paper describes a new macroscopic, phenomenological model of the skeletal muscle excitation-contraction coupling process, as represented by four principal and consecutive compartments (biophysical, biochemical, and biomechanical phases) characteristic of isometric excitation-contraction coupling in mammalian skeletal muscle, and coupled by a system of simultaneous, first-order linear ordin...

Electrical Models of Excitation-Contraction Coupling and Charge Movement in Skeletal Muscle

A B ST R A C T The consequences of ionic current flow from the T system to the sarcoplasmic reticulum (SR) of skeletal muscle are examined. The Appendix analyzes a simple model in which the conductance gx, linking T system and SR, is in series with a parallel resistor and capacitor having fixed values. The conductance gx is supposed to increase rapidly with depolarization and to decrease slowly...