Evolutionary Computation-Based Memetic Algorithm Against Genetic Algorithm to Improve PCR-RFLP Assay Primers of SNP Genotyping
نویسندگان
چکیده
منابع مشابه
Natural SNP-RFLP Primer Design using Memetic Algorithm
Single nucleotide polymorphisms (SNPs) can be genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Before performing PCR-RFLP for SNP genotyping, a feasible primer pair observes numerous constraints and an available restriction enzyme discriminate the target SNP, are required, here we called it natural SNP-RFLP primer design. Design the natural SNP-RFLP pr...
متن کاملSNP Cutter: a comprehensive tool for SNP PCR–RFLP assay design
The Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) is a relatively simple and inexpensive method for genotyping single nucleotide polymorphisms (SNPs). It requires minimal investment in instrumentation. Here, we describe a web application, 'SNP Cutter,' which designs PCR-RFLP assays on a batch of SNPs from the human genome. NCBI dbSNP rs IDs or formatted SNPs are ...
متن کاملMultiplex PCR Assay Design by Hybrid Multiobjective Evolutionary Algorithm
Multiplex Polymerase Chain Reaction (PCR) assay is to amplify multiple target DNAs simultaneously using different primer pairs for each target DNA. Recently, it is widely used for various biology applications such as genotyping. For sucessful experiments, both the primer pairs for each target DNA and grouping of targets to be actually amplified in one tube should be optimized. This involves mul...
متن کاملAn Order Based Memetic Evolutionary Algorithm for Set Partitioning Problems
Metaheuristic algorithms, such as simulated annealing, tabu search and evolutionary algorithms, are popular techniques for solving optimization problems when exact methods are not practical. For example, the run times required to obtain exact solutions to many common combinatorial problems grow exponentially (or worse) with the problem size, and as a result, solving even a relatively modest siz...
متن کاملOptimal Recloser Placement by Binary Differential Evolutionary Algorithm to Improve Reliability of Distribution System
In this context, a novel structure has been proposed for simple Differential Evolutionary (DE) algorithm to solve optimal recloser placement. For this, an operator is added to DE algorithm to adapt concept of the problem. Other contribution of this work is formulating a novel objective function. The proposed objective function has been formulated to improve four reliability indices which consis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: IEEE Access
سال: 2018
ISSN: 2169-3536
DOI: 10.1109/access.2018.2884189