Evolution and replacement of Candida albicans strains during recurrent vaginitis demonstrated by DNA fingerprinting
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چکیده
منابع مشابه
Evaluation of Candida Vaginitis Epidemic Caused by Candida Albicans in Women of Kazerun City
Introduction: Candida albicans is one of the most common causes of vaginitis and one of the most important reasons for women to visit health centers. The aim of this study was to determine Candida albicans infection and its related factors in women in Kazerun. Methods: This cross-sectional study was performed in 2017 on 150 samples extracted from the laboratory. Swab specimens were prepared fr...
متن کاملCandida albicans strain maintenance, replacement, and microvariation demonstrated by multilocus sequence typing.
We typed 165 Candida albicans isolates from 44 different sources by multilocus sequence typing (MLST) and ABC typing of rRNA genes and determined their homozygosity or heterozygosity at the mating-type-like locus (MTL). The isolates represented pairs or larger sets from individual sources, which allowed the determination of strain diversity within patients. A comparison of replicate sequence da...
متن کاملSecretory Aspartyl Proteinases Cause Vaginitis and Can Mediate Vaginitis Caused by Candida albicans in Mice
UNLABELLED Vaginal inflammation (vaginitis) is the most common disease caused by the human-pathogenic fungus Candida albicans. Secretory aspartyl proteinases (Sap) are major virulence traits of C. albicans that have been suggested to play a role in vaginitis. To dissect the mechanisms by which Sap play this role, Sap2, a dominantly expressed member of the Sap family and a putative constituent o...
متن کاملDNA fingerprinting of serial Candida albicans isolates obtained during itraconazole prophylaxis in patients with AIDS.
During a randomized double-blind placebo-controlled study testing the efficacy of itraconazole for prophylaxis of systemic and mucosal fungal infections in patients with acquired immune deficiency syndrome, 298 patients were enrolled with 295 evaluable. Of those, 46 patients were considered prophylaxis failures because of recurrent oral or esophageal candidiasis. Oropharyngeal fungal cultures w...
متن کاملFluconazole Resistance Candida albicans in Females With Recurrent Vaginitis and Pir1 Overexpression
BACKGROUND Some genes may be associated with Candida albicans resistance to azoles. Pir1 gene is described as responsible to induce resistance in C. albicans. OBJECTIVES The current study aimed to find the relationship between fluconazole resistance and Pir1 protein (Pir1p) overexpression in the females with recurrent C. albicans vaginitis requiring longer fluconazole therapy. PATIENTS AND ...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 1994
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.32.11.2646-2654.1994