Evaluation Of The Connection Between Serum Tumor Necrosis Factor-Alpha, Transforming Growth Factor-Beta, Interleukin-10 And Alanine Aminotransferase Levels And Treatment In Naive Chronic Hepatitis C Patients

Patients with naive CHC were included in the study. All of patients genotype 1b and all them treated pegylated interferon ribavirin combined. 43 people patient group control group. Of both groups, 23 male 20 female. The mean age was 49.54±13.02, 47.98±14.1. Serum alanine aminotransferase (ALT), TNF-alpha, TGF-beta, IL-10 values studied groups. To measure TGF-beta values, 10 cc venous blood taken into biochemistry tubes containing paraffin. Blood centrifuged at 5000 rpm for 5 minutes. These procedures carried out within 1 hour. After centrifugation, serums placed Eppendorf tube stored a deep freezer -80 degrees until study day. cytokine levels measured by ELISA method according to kit procedures. Levels Human TNF-alpha (DIAsource - Kit), IL-10-ELISA ELISA-Multispecies kit) 0. 12. And it from serum samples week 48 single sample Values detected recorded as pg/ml. ALT groups routinely laboratory our hospital. Combined treatment started case evaluated terms response 12th 48th weeks. They divided 2 responding non-responsive treatment. these two 0-12 weeks, 12-48 weeks 0-48. Pairwise comparisons made Finally, 0, 12, compared ALT. Spearman's correlation test used statistical analysis. limit significance p<0.05 interpretations. SPSS (version: 17.0) package program A difference found who responded