Eukaryotic DNA Replication Origins
نویسندگان
چکیده
منابع مشابه
Making sense of eukaryotic DNA replication origins.
DNA replication is the process by which cells make one complete copy of their genetic information before cell division. In bacteria, readily identifiable DNA sequences constitute the start sites or origins of DNA replication. In eukaryotes, replication origins have been difficult to identify. In some systems, any DNA sequence can promote replication, but other systems require specific DNA seque...
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A new insight is revealed by Anglana et al. 128 kb of the single, primary (high frequency) oriGNA13. mary origin represses initiation at the secondary origins. Moreover, increasing the nucleotide pool by addition of DNA precursors to the culture medium reduces the frequency of initiation at secondary origins, whereas reducing the nucleotide pool by addition of hydroxyurea (a specific inhibitor ...
متن کاملWhere it all starts: eukaryotic origins of DNA replication.
Chromosomal origins of DNA replication in eukaryotic cells not only are crucial for understanding the basic process of DNA duplication but also provide a tool to analyze how cell cycle regulators are linked to the replication machinery. During the past decade much progress has been made in identifying replication origins in eukaryotic genomes. More recently, replication initiation point (RIP) m...
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SUMMARY DNA replication, a central event for cell proliferation, is the basis of biological inheritance. The identification of replication origins helps to reveal the mechanism of the regulation of DNA replication. However, only few eukaryotic replication origins were characterized not long ago; nevertheless, recent genome-wide approaches have boosted the number of mapped replication origins. T...
متن کاملGenomic specification and epigenetic regulation of eukaryotic DNA replication origins.
Identification of DNA replication origins (ORIs) at a genome-wide level in eukaryotes has proved to be difficult due to the high degree of degeneracy of their sequences. Recent structural and functional approaches, however, have circumvented this limitation and have provided reliable predictions of their genomic distribution in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, ...
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ژورنال
عنوان ژورنال: Cell
سال: 2003
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(03)00604-4