Estimation of glomerular filtration rate from the serum creatinine concentration.

Estimation of glomerular filtration rate from the serum creatinine concentration.

In patients with renal failure the dose of renally excreted drugs should be reduced in proportion with the degree of impairment of glomerular filtration: in this situation it is appropriate to measure the glomerular filtration rate in order to determine accurately the correct dose. However, as 24 hour urine based creatinine clearance measurements are time consuming and inaccurate, the parameter...

Estimation of glomerular filtration rate from height/plasma creatinine ratio.

Estimation of glomerular filtration rate from plasma creatinine concentration in children of various ages.

The relation between the true plasma creatinine concentration (Pc) and the glomerular filtration rate corrected for body surface area (GFR/SA) was investigated in 108 individuals, and the following formula was derived: GFR/SA (ml/min per 1-73m2SA) = 0-43 Ht (cm)/Pc (mg/100 ml). This formula was tested in a second group of 83 children, and its accuracy and precision was compared to the 24-hour c...

Estimation of glomerular filtration rate from serum creatinine and cystatin C in octogenarians and nonagenarians

BACKGROUND Equations to estimate GFR have not been well validated in the elderly and may misclassify persons with chronic kidney disease (CKD). We measured GFR and compared the performance of the Modification of Diet in Renal Disease (MDRD), the Chronic Kidney Disease-Epidemiology Collaboration (CKD-Epi) and the Berlin Initiative Study (BIS) equations based on creatinine and/or cystatin C in oc...

Serum creatinine and glomerular filtration rate: perception and reality.

Na primeira leitura, o relato de Spanaus et al.(13) no Clinical Chemistry pode ser descartado como apenas mais uma comparação entre biomarcadores séricos para taxa de filtração glomerular (TFG). Entretanto, os resultados e as conclusões deverão estimular uma reavaliação da concepção errônea, amplamente disseminada, de que a creatinina sérica é um biomarcador insensível da TFG e uma afirmação do...